The use of hypochlorous acid in an OXA-48 multiple drug-resistant Enterobacteriacea-infected lower leg wound – a case study

Abstract

Resistance among pathogenic bacteria to standard antimicrobial agents used for chemotherapy has emerged as a major public health concern globally and is expanding at an alarming rate. The problem is further compounded by the inappropriate and irrational use of antimicrobials, which has driven the emergence of multidrug-resistant (MDR) infection. Here, we present a case on OXA-48 Klebsiella pneumoniae wound infection, a carbapenemase-producing Enterobacteriaceae MDR Gram-negative bacteria that was treated successfully with hypochlorous acid gauze dressings retained with crepe bandages. This approach was successful in eradicating the OXA-48 infection, and further instrumental in the control of inflammation, which allowed the wound to heal completely within 60 days.